Introduction to macromolecules and to key topics of cellular and molecular biology; the emphasis will be on DNA replication, gene transcription, small RNA mediated gene regulation, RNA processing, proteins translation, protein trafficking, mutagenesis, cell division and apoptosis.
Principles of biochemistry; molecular and cell biology. General introduction to cell structure and function. Genetics, bioenergetics, anatomy and physiology; introduction to biotechnology.
Principles of biochemistry; molecular and cell biology. General introduction to cell structure and function. Genetics, bioenergetics, anatomy and physiology; introduction to biotechnology.
Essentials of how signaling within and between cells allows organization into functional tissues and organs: including the topics of cell adhesion and locomotion, cell polarity, immunology, tumorigenesis, intercellular signaling, cell and tissue size, the function of tissue organizers, specification of the general body plan, regeneration, developmental timing, and aging.
Methods in molecular biology and genetic engineering, chromosomes, extrachromosomal replicons, transposable elements and retroviruses, repair systems, somatic DNA recombination and hypermutation in the immune system, mRNA stability and localization, catalytic RNA and operons.
Human Genetics: the mapping of traits within the human genome, genetic markers, imprinting and heritable epigenetic marks, both Mendelian and non-Mendelian genetic diseases, disease associated with multiple loci, and new technologies used to investigate the genetic causes of illness.
Student will extend their knowledge from Biochemistry I by exploring the biochemistry of signal transduction, glycolysis, gluconeogenesis, the Krebs cycle, photosynthesis, fatty acids, steroids, nucleic acids, and amino acids.
Comprehensive introduction to the field of genomics and bioinformatic tools necessary for analyzing and interpreting genomic data. Collection and storage of sequence information. Investigation of complex biological processes using genomic data at various levels (DNA, mRNA and protein). Next generation sequencing technologies and sequence data formats, assembly and mapping of raw sequence data, gene prediction and annotation, transcriptomics, functional genomics, genome evolution, genome-wide profiling, phylogenomics and population genomics.
Proteomics and function, fundamentals of mass spectrometry (MS), tandem MS, chemical and posttranslational modifications, protein identification, data mining, protein complexes, protein folding, MS genotyping, high throughput; recently developed proteomics methods and their applications; focus on the recent scientific literature in this field including quantitative comparison of healthy and disease proteomes, the comprehensive analysis of protein-protein interactions in different cell types, and new approaches to analyze cellular signaling pathways and the subcellular-organelle and cell surface proteomes.
Basic properties of the cell cycle, model organisms and basic methods in cell cycle studies, cyclin dependent kinases and regulation of their activity, control of chromosome duplication, chromosomes segregation, mitotic spindle, cytokinesis and cell cycle checkpoints: (i.e. Start, DNA damage response, spindle assembly checkpoint)
Function of different neuronal cell types and the larger organization of the mammalian nervous system: The topics include the molecular details of synaptic connectivity and its relationship to learning and memory and the causes of neurodegenerative disease.
Regulation of blood glucose, insulin resistance, liver metabolism, diabetes, lipid synthesis, obesity, cancer cell metabolism, the Warburg effect, mitochondria, nuclear receptors, protein acetylation, caloric restriction, longevity, hormones, endocrine regulation of tissue function, cancer cachexia.
Proteomics and function, fundamentals of mass spectrometry (MS), tandem MS, chemical and posttranslational modifications, protein identification, data mining, protein complexes, protein folding, MS genotyping, high throughput; recently developed proteomics methods and their applications; focus on the recent scientific literature in this field including quantitative comparison of healthy and disease proteomes, the comprehensive analysis of protein-protein interactions in different cell types, and new approaches to analyze cellular signaling pathways and the subcellular-organelle and cell surface proteomes.
Basic properties of the cell cycle, model organisms and basic methods in cell cycle studies, cyclin dependent kinases and regulation of their activity, control of chromosome duplication, chromosomes segregation, mitotic spindle, cytokinesis and cell cycle checkpoints: (i.e. Start, DNA damage response, spindle assembly checkpoint)
Function of different neuronal cell types and the larger organization of the mammalian nervous system: The topics include the molecular details of synaptic connectivity and its relationship to learning and memory and the causes of neurodegenerative disease.
Regulation of blood glucose, insulin resistance, liver metabolism, diabetes, lipid synthesis, obesity, cancer cell metabolism, the Warburg effect, mitochondria, nuclear receptors, protein acetylation, caloric restriction, longevity, hormones, endocrine regulation of tissue function, cancer cachexia.
Basic mathematical notation and formulations in mechanical engineering: tensor algebra, indicial notation, coordinate transformations, basic tensor operations in indicial notation. Units and unit conversions. Key mechanical engineering concepts and their use in mechanical design. Introduction to mechanical design: forces in structures, materials and stresses, materials selection. Major fields of specialization in mechanical engineering. Design process and practical experience in team projects.
Introduction to engineering materials such as metals, ceramics and glasses, polymers, and composites. Crystalline structure and defects. Elastic and plastic deformations of materials. Hardness. Creep and stress relaxation. Visco-elastic deformation. Thermal behavior. Failure analysis. Phase diagrams. Heat treatment.
First and second laws. Energy conservation and entropy. Analysis of engineering systems, such as refrigeration cycles and combustion engines. Vapor/liquid equilibrium,applications in mixture behaviours.
Introduction to the kinematics and dynamics of particles and rigid bodies. Energy and momentum concepts.
Characteristics of fluids, fluid statics, Bernoulli equation, fluid kinematics, boundary layers, viscous flows and turbulence.
Steady state and transient conduction. Convection. Internal and external flows. Radiation. Analysis and design of heat exchange equipment.
Modeling and dynamic analysis of mechanical systems. Feedback control.