Cells have elaborate mechanisms for controlling cell proliferation and differentiation. In this course, we will explore in molecular detail the intricate signaling pathways that are important for cell behavior, with a major focus on those pathways that are conserved widely among many species.

The key concepts and techniques related to the prokaryotic and eukaryotic cytoskeleton including the molecular mechanism of the core building blocks, nucleators, molecular motors and regulators of actin and microtubule cytoskeleton and intermediate filaments, roles of the cytoskeleton in the physiology of individual cells, tissues and organisms and their implications in human disease, emerging techniques to study the cytoskeletal components such as advanced microscopy.

Synthetic lethality. Second-site suppressors. High-copy suppressors. Epistasis. Random and library-based mutagenesis during genetic screens. Deep mutational scanning.

The advanced methodology used for modern biological science research. Topics include the interpretation of data gained from both hypothesis-driven and high-throughput experiments from research articles focusing on DNA repair, DNA replication, transcription, cell cycle, organelle biogenesis, proteomics and genetics.

Cells have elaborate mechanisms for controlling cell proliferation and differentiation. In this course, we will explore in molecular detail the intricate signaling pathways that are important for cell behavior, with a major focus on those pathways that are conserved widely among many species.

The journey of a fertilized egg to turn into a fully developed adult, the molecular mechanisms that regulate the animal development in two vertebrate (mouse, fish) and two invertebrate (fly, worm) models; body plan formation, organogenesis, morphogenesis, regeneration and ageing.

The key concepts and techniques related to the prokaryotic and eukaryotic cytoskeleton including the molecular mechanism of the core building blocks, nucleators, molecular motors and regulators of actin and microtubule cytoskeleton and intermediate filaments, roles of the cytoskeleton in the physiology of individual cells, tissues and organisms and their implications in human disease, emerging techniques to study the cytoskeletal components such as advanced microscopy.

Detailed literature-based course to investigate nuclear receptor signaling in disease. Advanced molecular biology techniques to investigate nuclear receptor signaling. Nuclear receptor pharmacology.

Synthetic lethality. Second-site suppressors. High-copy suppressors. Epistasis. Random and library-based mutagenesis during genetic screens. Deep mutational scanning.

Statics: force, moment, equilibrium of rigid bodies, moment of inertia of areas, structural analysis of trusses, frames and machines, internal forces and moments. Mechanics of materials: normal and shear stresses and strains, mechanical properties of materials, axial load, torsion, bending, transverse shear, combined loadings, transformation of stresses, principal stresses and Mohr's circle, and beam deflection.

Formulation of the mechanical engineering design process. Spatial representation, visual thinking and graphical presentation. Conceptual product design. Use of Computer Aided Design tools. Design exercises.

Characteristics of fluids, fluid statics, Bernoulli equation, fluid kinematics, boundary layers, viscous flows and turbulence.

Basic concepts to analyze and design different machine components. Design of assemblies to meet certain requirements.

MICROS &MECH. BEHAV. OF MATERPrerequisite: MECH 202 There are so many different materials used in industry and it is impossible to know all different alloys and their specific characteristics. But, if the basic recipes of material preparation methods are known, one may easily predict and improve the mechanical properties of materials. The characteristics of each material group reveals how they can be processed and the processing defines the microstructure, which, consecutively, determines the properties of material and its suitability to the field of application. In this course, an introduction to microstructure of materials will be followed by the information on how to change this structure and hence determine the final properties of products. While it allows students to advance their knowledge that they have learned in MECH 202 – Engineering Materials course, it prepares them to MECH 306 – Manufacturing Processes course by linking the contents of these two required area courses. In each section, case studies will be introduced to illustrate how the scientific principals control the properties of real engineering materials.

Basic instrumentation and measurement techniques for mechanical engineering systems. Experimentation with thermal systems and machines to demonstrate thermodynamics, fluid, heat transfer, dynamics and control concepts. Data acquisition, analysis, and presentation techniques.

Material and manufacturing process selection in automotive engineering, product design and development, quality control and testing methods, general introduction to other fields of automotive engineering.

Teaches deterministic vibratory motion of mechanical systems. Includes free, forced-harmonic, forced-periodic, and forced-transient vibration of single-degree-of-freedom, multiple-degree-of-freedom, and continuous systems. It also gives an introduction to the Finite Element Method.

Foundations of fluid mechanics introduced at an advanced level. Aspects of kinetic theory as it applies to formulation of continuum fluid dynamics. Introduction to tensor analysis and derivation of Navier Stokes equations and energy equation for compressible fluids. Boundary conditions and surface phenomena. Viscous flows, boundary layer theory, potential flows and vorticity dynamics. Introduction to turbulence and turbulent flows.

The principles of rocket propulsion system design and analysis. The fundamental aspects of physics and chemistry of rocket propulsion will be discussed. The concentration will be on the design and analysis of chemical propulsion systems including liquids, solids and hybrids. Non-chemical propulsion concepts such as electric and nuclear rockets will also be covered. Finally launch vehicle design and optimization issues including trajectory calculations will be discussed.

Topics will be announced when offered.

A capstone design course where students apply engineering and science knowledge in a mechanical engineering design project. Development, design, implementation and management of a project in teams under realistic constraints and conditions. Emphasis on communication, teamwork and presentation skills.

Material and manufacturing process selection in automotive engineering, product design and development, quality control and testing methods, general introduction to other fields of automotive engineering.

Foundations of fluid mechanics introduced at an advanced level. Aspects of kinetic theory as it applies to formulation of continuum fluid dynamics. Introduction to tensor analysis and derivation of Navier Stokes equations and energy equation for compressible fluids. Boundary conditions and surface phenomena. Viscous flows, boundary layer theory, potential flows and vorticity dynamics. Introduction to turbulence and turbulent flows.