The advanced methodology used for modern biological science research. Topics include the interpretation of data gained from both hypothesis-driven and high-throughput experiments from research articles focusing on DNA repair, DNA replication, transcription, cell cycle, organelle biogenesis, proteomics and genetics.

Proteomics and function, fundamentals of mass spectrometry (MS), tandem MS, chemical and posttranslational modifications, protein identification, data mining, protein complexes, protein folding, MS genotyping, high throughput; recently developed proteomics methods and their applications; focus on the recent scientific literature in this field including quantitative comparison of healthy and disease proteomes, the comprehensive analysis of protein-protein interactions in different cell types, and new approaches to analyze cellular signaling pathways and the subcellular-organelle and cell surface proteomes.

Cells have elaborate mechanisms for controlling cell proliferation and differentiation. In this course, we will explore in molecular detail the intricate signaling pathways that are important for cell behavior, with a major focus on those pathways that are conserved widely among many species.

The journey of a fertilized egg to turn into a fully developed adult, the molecular mechanisms that regulate the animal development in two vertebrate (mouse, fish) and two invertebrate (fly, worm) models; body plan formation, organogenesis, morphogenesis, regeneration and ageing.

Function of different neuronal cell types and the larger organization of the mammalian nervous system: The topics include the molecular details of synaptic connectivity and its relationship to learning and memory and the causes of neurodegenerative disease.

Fundamental aspects of molecular and cellular biology of cancers with respect to developing cancer therapies; basic principles of cancer treatment, molecularly targeted therapies, cytotoxic therapies, drug discovery approaches, drug delivery systems, cell-based and gene therapies; discussion of research and review articles.

The key concepts and techniques related to the molecular and cellular basis of microbial pathogenesis including the exploitation of mammalian host cells by medically relevant prokaryotic and eukaryotic pathogens, molecular mechanisms of infectious diseases, immune response to infections, the role of pathogenic and host factors in disease and emerging techniques to study the basis of microbial pathogenesis and disease.

Advanced theoretical and applied methods in modern genomic research; classical and novel approaches used to solve problems in functional genomics and system biology; modern sequencing techniques and their utilization in biomedical research.

Formation of organelles, regulation of the abundance and function of organelles, interaction and cooperation of organelles with each other; proteins and other macromolecules: how they are synthesized within or imported into organelles; disease cased by deficiencies in organelle function.

Detailed literature-based course to investigate nuclear receptor signaling in disease. Advanced molecular biology techniques to investigate nuclear receptor signaling. Nuclear receptor pharmacology.

Basic mathematical notation and formulations in mechanical engineering: tensor algebra, indicial notation, coordinate transformations, basic tensor operations in indicial notation. Units and unit conversions. Key mechanical engineering concepts and their use in mechanical design. Introduction to mechanical design: forces in structures, materials and stresses, materials selection. Major fields of specialization in mechanical engineering. Design process and practical experience in team projects.

Introduction to engineering materials such as metals, ceramics and glasses, polymers, and composites. Crystalline structure and defects. Elastic and plastic deformations of materials. Hardness. Creep and stress relaxation. Visco-elastic deformation. Thermal behavior. Failure analysis. Phase diagrams. Heat treatment.

First and second laws. Energy conservation and entropy. Analysis of engineering systems, such as refrigeration cycles and combustion engines. Vapor/liquid equilibrium,applications in mixture behaviours.

Introduction to the kinematics and dynamics of particles and rigid bodies. Energy and momentum concepts.

Steady state and transient conduction. Convection. Internal and external flows. Radiation. Analysis and design of heat exchange equipment.

Modeling and dynamic analysis of mechanical systems. Feedback control.

Materials: structure of metals, testing for mechanical properties, physical properties, heat treatments, iron and steel, non-ferrous metals, polymers and composite materials. Processes: casting, rolling, forging, extrusion, sheet-metal forming, powder-metallurgy, polymer and composite processing, rapid-prototyping and machining (turning and milling). Engineering metrology and instrumentation. Introduction to CNC coding and simulations.

Introduction to programming in MATLAB, foundations in computing, root finding, solving systems of linear equations with direct and iterative methods, solving nonlinear equations of multi-variables, curve-fitting, numerical differentiation and integration, solving ODEs and PDEs using Eulerian time-marching scheme and finite difference method (FDM), solving many engineering problems related with initial- and boundary-value problems, Laplace and heat equations.

Introduction to finite element method (FEM) as a computational tool for stress analysis. Basic theory with emphasis on linear elasticity and application of the FEM to various engineering problems: stress analysis, natural modes and frequencies of vibration, heat transfer, mechanics of micro and nano structures. Development of finite element code and use of commercial codes for practical applications.

Numerical methods for elliptic, parabolic, hyperbolic and mixed type partial differential equations arising in fluid flow and heat transfer problems. Finite-difference, finite-volume and some finite-element methods. Accuracy, convergence, and stability; treatment of boundary conditions and grid generation. Review of current methods. Assignments require programming a digital computer.

Overview of MEMS materials and fabrication techniques; mechanical concepts and components; transduction techniques; MEMS sensors.

A capstone design course where students apply engineering and science knowledge in a mechanical engineering design project. Development, design, implementation and management of a project in teams under realistic constraints and conditions. Emphasis on communication, teamwork and presentation skills.

A capstone design project on an industrially relevant problem. Students work on teams in consultation with various faculty and industrial members.